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. 2020 Feb 21;21(4):1479. doi: 10.3390/ijms21041479

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A). RNA-RNA interactome in the HCV genome. RNA-RNA interactome in the HCV genome. Secondary structure model of the RNA genome and the structural tuning events required for the execution of the HCV cycle. Structural domains are designated by their names. Diagrams show the RNA domains, indicated with thick black lines, and their interactions, indicated by dashed blue lines. Their roles for different steps of the viral cycle – translation (A), replication (C) and transitions between them (B), as well as RNA genome packaging (D) – have been proposed.

(A). RNA-RNA interactome in the HCV genome. RNA-RNA interactome in the HCV genome. Secondary structure model of the RNA genome and the structural tuning events required for the execution of the HCV cycle. Structural domains are designated by their names. Diagrams show the RNA domains, indicated with thick black lines, and their interactions, indicated by dashed blue lines. Their roles for different steps of the viral cycle – translation (A), replication (C) and transitions between them (B), as well as RNA genome packaging (D) – have been proposed.