Figure 6.

Long-range RNA–RNA contacts in representative RNA viruses with linear genomes. This figure shows the proposed conserved secondary structural elements and sequence motifs within the 5′ and 3′ ends of retroviruses, such as HIV-1 (A) and DENV-2 (representative of flaviviruses) (B) involved in genome circularization. The ORF and the UTRs (RU5 and U3R for retroviruses) are indicated. Thin colored lines denote long-distance RNA–RNA interactions between genomic termini. The pseudoknot elements (PK1, PK2, and PK3) are indicated by dashed black lines.