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Gasdermin D (GSDMD)-mediated cell death. When physiological or pathological stimuli activates inflammasomes, ASC is recruited to lead to activation of caspase1. GSDMD is cleaved by caspase1 to release active GSDMD-N, translocating to the plasma membrane to induce pyroptosis. Meanwhile, GSDMD-N can also permeabilize the mitochondrial membrane to trigger the mitochondrial apoptotic pathway downstream of inflammasome activation, inducing cell apoptosis.
