Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Gasdermin E (GSDME)-dependent cell death. Internal stress arising from stimuli (such as iron) lead to activation of Bax and release of Cyt c to stimulate caspase9 activation and induce caspase3/GSDME-mediated cell pyroptosis (green arrows). Meanwhile, the extrinsic stimuli activate caspase8 and caspase3 to cleave GSDME, and GSDME permeabilizes the mitochondrial membrane to release Cyt c, inducing caspase3-mediated apoptosis (black arrows).
