Table 1.
Compounds inhibiting pyroptosis signal pathway to treat inflammatory diseases.
| Classification | Compounds | Inflammatory Diseases | Mechanisms of Pyroptosis Inhibition |
References |
|---|---|---|---|---|
| Reagents | Atorvastatin | Atherosclerosis | lncRNA NEXN-AS1/NEXN /NLRP3/caspase1/GSDMD | [56] |
| MCC950 | Cognitive impairment | NLRP3/caspase1 | [57] | |
| Anakinra | Liver inflammation | NLRP3/caspase1 | [58] | |
| Kanglexin | Ischemic heart disease | NLRP3/caspase1/GSDMD | [59] | |
| Chitosan hydrogel | Myocardial Infarction | Caspase1/GSDMD | [60] | |
| Ethyl pyruvate | Endotoxemia and sepsis | Caspase11/GSDMD | [61] | |
| Ac-YVAD-CMK | Periodontal diseases | Caspase1/GSDMD/IL-1β | [62] | |
| Natural products | Huai Qi Huang | Arthritis | Caspase1/GDSMD | [63] |
| Andrographolie | Lung injury | AIM2/caspase1/GSDMD | [64] | |
| Dendrobium alkaloids | CIR impairment | Caspase1/ GSDMD | [65] | |
| Resveratrol | Preeclampsia | TXNIP/NLRP3/caspase1 /GSDMD |
[18] |
CIR: cerebral ischemia-reperfusion. NEXN-AS1: nexilin F-actin binding protein antisense RNA 1. NLRP3: NOD-like receptor protein 3. GSDMD: gasdermin D.IL-1β: Interleukin1β.AIMs: absent in melanoma like receptors.TXNIP: thioredoxin-interacting protein.