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. 2020 Feb 1;12(2):332. doi: 10.3390/cancers12020332

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A-1331852 synergistically increased regorafenib cytotoxicity against different hepatoma cell lines. (A,B) MTT assays to test the A-1331852 and ABT-199 effect on regorafenib cytotoxicity in different liver cell lines (HepG2, Hep3B, and PLC/PRF/5) were performed, synergy calculated using HSA analysis, and results displayed with heat maps (blue synergy vs. red antagonism). (C,D), Crystal Violet staining was performed after 3 days of treatment with vehicle (C), regorafenib (R), and/or A-1331852/ABT-199 (A) in HepG2, Hep3B, and PLC/PRF/5 cell cultures. (n = 3) * p < 0.05 vs. control.