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. 2020 Feb 1;12(2):332. doi: 10.3390/cancers12020332

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Alterations in BCL-xL mRNA levels and BCL-xL/MCL-1 ratio in HCC patients. (A) BCL-xL and (B) BCL-xL/MCL-1 mRNA levels were measured by qPCR in healthy liver (n = 10) and in cirrhotic and tumoral tissue from HCC patients (n = 12) with Hepatitis C virus (HCV) and/or Ethanol (EtOH etiology. * p < 0.05 vs. control. (C) BCL-xL and (D) BCL-xL/MCL-1 mRNA levels were measured by qPCR in a commercial mRNA array with healthy liver (n = 8) and tumoral tissue from HCC patients in different stages (I-II, n = 14; IIIA-IV, n = 12). (E,F) Representation of survival probability depending on BCL-xL expression (blue, high; purple, low) in patients with liver and colorectal cancer, respectively.