Table 3.
Phospho-Smad3L/C and fibrosis stage are independent predictors of HCC occurrence.
| Variables | Category | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | p Value | Hazard Ratio (95% CI) | p Value | ||
| Fibrosis stage | Low (1 and 2) | ||||
| High (3 and 4) | 8.823 (1.023–76.12) | 0.04766 | 22.36 (1.269–394.1) | 0.0338 | |
| Necroinflammatory grade | Low (0 and 1) | ||||
| High (2 and 3) | 1.768 (0.3563–8.771) | 0.4857 | |||
| NAFLD activity score | <5 | ||||
| ≥5 | 0 | 0.999 | |||
| pSmad3C positivity | High (3 and 4) | ||||
| Low (1 and 2) | 13.25 (1.538–114.2) | 0.01868 | 15.61 (1.254–194.3) | 0.0327 | |
| pSmad3L positivity | Low (1 and 2) | ||||
| High (3 and 4) | 10.32 (1.866–57.05) | 0.007479 | 18.53 (1.712–200.6) | 0.0163 | |