Table 1.

Genetic mutations affecting the ER-to-Golgi trafficking machinery in neurological diseases.

Mutated Genes	Neurological Diseases	References
SEC31A	Syndrome characterized by developmental delay, microcephaly, and epilepsy	[80]
SEC24B	Neural tube defect	[81]
TECPR2	Hereditary spastic paraplegia	[83,84]
cTAGE5	Idiopathic basal ganglia calcification	[85]
TFG	Hereditary spastic paraplegia, Charcot-Marie-Tooth disease, hereditary motor and sensory neuropathy	[86,87,88,89,90]
TRAPPC6A	Neurodevelopmental syndrome with dysmorphic features	[91]
TRAPPC6B	Neurodevelopmental disorders with microcephaly, epilepsy and autism symptoms	[92]
TRAPPC9	Intellectual disability frequently associated with microcephaly	[93,94]
TRAPPC2L	Encephalopathy and rhabdomyolysis	[95]
TRAPPC12	Childhood encephalopathy	[96]