Figure 2.
Genetic alterations of FGFR3 and HRAS and their impact on gene expression. (A) Schematic description of genomic and transcriptomic fusion constructs of FGFR3. Small (B) or large (C) genomic deletion of exon 5 generated HRAS transcripts including exon 6. (A–C) E and I refer to exon and intron, respectively. (D) Gene expression of HRAS in 5 cases with HRAS mutations in young-onset bladder cancer.