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Schematic illustration of an example of self-assembled pH-responsive doxorubicin loaded micelles. The micelles were formulated using hydrophilic PEG and hydrophobic pH-sensitive PAE. The micelles will remain stable at normal sites (pH = 7.4), only to respond at the targeted site with the desired pH (pH < 6.5). Abbreviations: PEG—poly(ethylene glycol), PAE—poly(β-amino esters) g-cholesterol, and DOX—doxorubicin. Adapted and modified with permission from [92].
