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. 2020 Feb 18;21(4):1370. doi: 10.3390/ijms21041370

Figure 4.

Figure 4

Oxygen consumption rate (OCR) measurement over time after 24 h of treatment of EC15 and EC40 for (A) butylone (filled and empty triangle, respectively), (B) pentylone (filled and empty square, respectively), and (C) MDPV (filled and empty diamond, respectively) with control (empty circle). Individual mitochondrial function parameters of EC15 and EC40 for (D) butylone (clear and grey diagonal bars, respectively), (E) pentylone (clear and grey horizontal bars, respectively), and (F) MDPV (clear and grey vertical bars, respectively): (i) basal respiration (## p < 0.01 vs. EC15 pentylone, and #### p < 0.0001 vs. EC15 MDPV), (ii) proton leak (## p < 0.01 vs. EC15 MDPV), (iii) maximal respiration (#### p < 0.0001 vs. EC15 pentylone and EC15 MDPV), (iv) non-mitochondrial respiration, and (v) spare respiratory capacity (#### p < 0.0001 vs. EC15 pentylone, and ## p < 0.01 vs. EC15 MDPV). The spare respiratory capacity was calculated from the difference between maximal and basal respiration. Data are Mean ± SD obtained from at least four independent experiments normalized to the % confluence of cells. Different to the control; * p < 0.1, *** p < 0.001 and **** p < 0.0001.