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. 2020 Feb 24;21(4):1533. doi: 10.3390/ijms21041533

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Abnormal apoptosis and inflammation response in beclin1^+/− liver. Expressions of mRNA in 16-month-old zebrafish evaluated by qRT-PCR for inflammation-related genes (A) and apoptotic-related genes (B). (C) Representative immunoblots showed the relative protein expression of tP53, IL-6. β-actin was used as the vehicle control. (D) The ratio of tP53/β-actin and IL-6/β-actin evaluated by NIH software Image J. (E) Immunofluorescence of liver tissues probed against mutated tP53. The nuclei of the necrosis hepatocytes indicated the genomic instability and DNA damage in tumor cells (yellow arrows). CV: central vein; NC: Necrosis. Data expressed as mean ± SD. * p < 0.05, ** p < 0.01, and *** p < 0.001.