Figure 2.
Mechanisms involved in microenvironment-mediated resistance to FLT3 inhibitors. 1. FLT3L/FLT3R-WT 2. FGF2/FGFR1 axis 3. SDF1/CXCR4 axis 4. CYP3A4-mediated degradation of FLT3 inhibitors (FLT3i) 5. GM-CSF or IL3/IL3R axis.
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