Figure 5.

Systemic immune response after calcium electroporation. A patient with cutaneous metastases from malignant melanoma was treated with electrochemotherapy using intravenous bleomycin. Four months after treatment of some of the multiple metastases, new metastases appeared. Two of these were treated (A), one with calcium electroporation and one with electrochemotherapy using intratumoral bleomycin, both with complete response within 6 months. Nine months after this treatment complete levelling of all cutaneous metastases appeared (B) as well as no or limited signs of previously enlarged lymph nodes on PET/CT scan (C,D). Adapted from Falk et al., 2018 [19].