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. 2020 Jan 22;12(2):271. doi: 10.3390/cancers12020271

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Representation of Gene Ontology annotations for genes from most strongly downregulated (PAL < 0; left) and upregulated (PAL > 0; right) (A) cytoskeleton, (B) DNA repair, (C) metabolic, (D) signaling pathways. Bubble size indicates the frequency of the Gene Ontology term in the underlying GOA database [54] (bubbles corresponding to more general terms are shown larger). “P” stands for process, “MP”—for metabolic process. Too general and non-informative gene ontology terms are not defined. No cytoskeleton pathways with PAL < 0 and DNA repair pathways with PAL > 0 could be identified in 80% and more samples.