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. 2020 Feb 3;12(2):341. doi: 10.3390/cancers12020341

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A). Differential expression profiles of the colorectal cancers (CRC) and healthy controls for predicting miRNA biomarkers. miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5pand miRNA-31-5p were significantly expressed different between the CRC patients and healthy controls. (B). miRNA-gene interaction network for the 12 predicted promising miRNA biomarkers. (C). miRNA-gene interaction network for miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p. (D). miRNA- long non-coding RNA (LncRNA) interaction network for miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p. (E). miRNA-disease network for miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p. miRNA-30e-5p were related to many other diseases. (F). miRNA-small molecular network for miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p. 5-fluorouracil therapy resistance was associated with miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p.

(A). Differential expression profiles of the colorectal cancers (CRC) and healthy controls for predicting miRNA biomarkers. miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5pand miRNA-31-5p were significantly expressed different between the CRC patients and healthy controls. (B). miRNA-gene interaction network for the 12 predicted promising miRNA biomarkers. (C). miRNA-gene interaction network for miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p. (D). miRNA- long non-coding RNA (LncRNA) interaction network for miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p. (E). miRNA-disease network for miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p. miRNA-30e-5p were related to many other diseases. (F). miRNA-small molecular network for miRNA-186-5p, miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p. 5-fluorouracil therapy resistance was associated with miRNA-30e-5p, miRNA-10b-5p, miRNA-21-5p and miRNA-31-5p.