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. 2020 Feb 3;12(2):341. doi: 10.3390/cancers12020341

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Distribution of pooled sensitivity and specificity, and their predicted posteriors in the Bayesian meta-analyses. (A). miRNA-186-5p showed pooled sensitivity: 0.73, prediction sensitivity: 0.74, pooled specificity 0.73 and prediction specificity: 0.74. (B). miRNA-30e-5p showed pooled sensitivity: 0.65, prediction sensitivity: 0.66, pooled specificity 0.6 and prediction specificity: 0.61. (C). miRNA-10b-5p showed pooled sensitivity: 0.63, prediction sensitivity: 0.64, pooled specificity: 0.6 and prediction specificity: 0.6). (D). miRNA-21-5p showed pooled sensitivity: 0.77, prediction sensitivity: 0.78, pooled specificity: 0.72 and prediction specificity: 0.73. (E). miRNA-31-5p showed pooled sensitivity: 0.77, prediction sensitivity: 0.77, pooled specificity: 0.63 and prediction specificity: 0.64. (F). Analyses of the multiple miRNA biomarkers revealed 0.85 for pooled sensitivity, 0.9 for pooled specificity, 0.89 for prediction sensitivity and 0.93 for the prediction specificity.

Distribution of pooled sensitivity and specificity, and their predicted posteriors in the Bayesian meta-analyses. (A). miRNA-186-5p showed pooled sensitivity: 0.73, prediction sensitivity: 0.74, pooled specificity 0.73 and prediction specificity: 0.74. (B). miRNA-30e-5p showed pooled sensitivity: 0.65, prediction sensitivity: 0.66, pooled specificity 0.6 and prediction specificity: 0.61. (C). miRNA-10b-5p showed pooled sensitivity: 0.63, prediction sensitivity: 0.64, pooled specificity: 0.6 and prediction specificity: 0.6). (D). miRNA-21-5p showed pooled sensitivity: 0.77, prediction sensitivity: 0.78, pooled specificity: 0.72 and prediction specificity: 0.73. (E). miRNA-31-5p showed pooled sensitivity: 0.77, prediction sensitivity: 0.77, pooled specificity: 0.63 and prediction specificity: 0.64. (F). Analyses of the multiple miRNA biomarkers revealed 0.85 for pooled sensitivity, 0.9 for pooled specificity, 0.89 for prediction sensitivity and 0.93 for the prediction specificity.