Table 3. Node-splitting analysis of proteinuria reduction.

Interventions	Direct effect	Indirect effect	Overall	P-Value
Placebo vs. enalapril	0.20 (−4.17, 4.58)	1.62 (−2.15, 5.46)	0.99 (−1.51, 3.70)	0.56
Placebo vs. losartan	1.43 (−0.55, 3.46)	0.04 (−5.67, 5.57)	1.27 (−0.40, 2.97)	0.57
enalapril vs. losartan	−0.17 (−3.41, 2.96)	1.24 (−3.57, 6.01)	0.29 (−2.24, 2.66)	0.55
Values are mean [SD]