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| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Multi‐centered versus single center | 44 | 22780 | Risk Ratio (M‐H, Random, 95% CI) | 1.32 [1.21, 1.44] |
| 2 Multi‐centered versus single center, randomized or controlled clinical trials | 7 | 1539 | Risk Ratio (M‐H, Random, 95% CI) | 1.47 [1.09, 1.98] |
