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. 2018 Nov 20;2018(11):MR000005. doi: 10.1002/14651858.MR000005.pub4

Klassen 2002.

Methods Identification of subsequent full‐length publications
  • Searched electronic database

    • CINAHL, Cochrane Central Register of Controlled Trials, PubMed, Embase, Web of Science, Current Contents, HealthStar between February and July 2000

    • Search completed by trained librarian

    • Searched by 'primary' author and keywords

    • Matched abstract to full‐length publication by

      • One common outcome

  • Contacted abstract authors directly (only for subset of authors as reported by Hartling 2004)

Data
  • Included 447 abstracts presented at the 1992, 1993, 1994, and 1995 Society for Pediatric Research meetings

  • Included all RCTs identified by handsearching abstract books

Comparisons
  • Proportion of abstracts published, overall and by meeting

  • Cumulative proportion of abstracts published

  • 'Positive' versus not 'positive'

  • 'Positive' versus not 'positive' for equivalence studies

  • Clinically very important or important versus somewhat important or not important

  • Government versus industry versus foundation versus internal versus no funding

  • Subspecialty

Outcomes
  • 264 of 447 abstracts published

  • 55/95 abstracts presented at the 1992 meeting, 70/109 at the 1993 meeting, 78/128 at the 1994 meeting, and 61/115 at the 1995 meeting published

  • Proportion of abstracts published by time

    • Cumulative proportion of abstracts published at 96 months showed proportion published = 58.1% (255/447 abstracts)

  • Factors related to proportion of abstracts published included

    • 162/235 'positive' (defined as experimental better than control ) versus 93/187 not 'positive' abstract results published

    • 64/77 'positive' (defined as significant results) versus 22/42 not 'positive' abstract results published for subset studied by Hartling 2004

    • 88/115 abstracts considered clinically very important or important versus 31/51 abstracts considered somewhat important or not important published for subset studied by Hartling 2004

    • 32/38 abstracts reporting government funding versus 37/43 abstracts reporting industry funding versus 6/8 abstracts reporting foundation funding versus 4/5 abstracts reporting internal funding versus 32/57 abstracts reporting no funding for subset studied by Hartling 2004

Notes
  • Pediatrics

  • Funding for study by Hartling by Alberta Heritage Foundation

  • Secondary publication by Hartling 2004 surveyed a subset of authors

Risk of bias
Item Authors' judgement Description
Sampling method? Yes Included all RCTs.
Search for publications? Yes Searched 7 databases and contacted abstract authors.
Follow‐up time? Yes All meetings had at least 5 years follow‐up.
Matching? No Matched by only 1 criterion.
Adjustment for confounding? Yes Examined association of meeting year, positive results, clinical importance, type funding, and subspecialty with publication using multivariable logistic regression analysis.