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. 2018 Nov 20;2018(11):MR000005. doi: 10.1002/14651858.MR000005.pub4

Ospina 2006.

Methods Identification of subsequent full‐length publications
  • Searched electronic database

    • CINAHL, MEDLINE, Embase to May 2004

    • Search completed by two investigators

    • Searched by all authors and keywords

    • Matched abstract to full‐length publication by

      • One author

      • Contents

      • Methodology

Data
  • Included 383 abstracts presented at the 1995 to 2003 Society for Academic Emergency Medicine meetings

  • Included all abstracts of controlled clinical trials and randomized clinical trials

Comparisons
  • Proportion of abstracts published, overall and by meeting

  • Median time to publication

  • Survival analysis of publication rate

  • 'Positive' versus not 'positive'

  • Authors endorsing treatment versus not

  • Parallel design versus crossover or factorial design

  • Multi‐centered versus single center

  • US versus non‐US origin

  • University affiliation versus no university affiliation

Outcomes
  • 194 of 383 abstracts published

  • 23/33 abstracts presented at the 1995 meeting, 24/40 at the 1996 meeting, 28/50 at the 1997 meeting, 27/42 at the 1998 meeting, 28/43 at the 1999 meeting, 27/44 at the 2000 meeting, 17/36 at the 2001 meeting, 17/52 at the 2002 meeting, and 3/43 at the 2003 meeting published

  • Proportion of abstracts published by time

    • Median time to publication = 32 months (95% CI = 23 to 41 months)

    • Survival analysis of proportion published at 108 months = 62.1%

  • Factors related to proportion of abstracts published included

    • 84/161 'positive' (defined as significant results) versus 110/222 not 'positive' abstract results published

    • 80/154 'positive' (defined as experimental better than control) versus 4/7 not 'positive' abstract results published

    • 108/210 abstracts with authors endorsing the treatment versus 86/173 abstracts with authors not endorsing the treatment published

    • 164/327 abstracts with parallel design versus 30/56 abstracts with crossover or factorial design published

    • 29/61 abstracts with multiple centers versus 165/322 abstracts with a single center published

    • 169/339 abstracts originating in the US versus 25/44 abstracts not originating in the US published

    • 138/253 abstracts with university affiliation versus 31/86 abstracts without a university affiliation published

Notes
  • Emergency medicine

  • Funding not reported

Risk of bias
Item Authors' judgement Description
Sampling method? Yes Included all abstracts that described specific study designs, so low risk of bias.
Search for publications? Yes Searched 3 databases.
Follow‐up time? Yes All meetings before 2001 had at least 48 months follow‐up. The other meetings had less than 48 months follow‐up.
Matching? Yes Matched by 3 different criteria.
Adjustment for confounding? Yes Examined association of meeting year, positive results, sample size, author conclusions, study design, multi‐center status, number of authors, university affiliation, and US origin with publication using multivariable logistic regression analyses.