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. 2018 Nov 20;2018(11):MR000005. doi: 10.1002/14651858.MR000005.pub4

Scherer 1994.

Methods Identification of subsequent full‐length publications
  • Searched electronic database

    • MEDLINE from year of presentation through 1992

    • Search completed by investigator

    • Searched by all authors

    • Matched abstract to full‐length publication by

      • All authors

      • Contents

  • Contacted abstract authors directly

Data
  • Included 93 abstracts presented at the 1988 and 1989 American Academy of Ophthalmology and Association for Research in Vision and Ophthalmology meetings

  • Included all abstracts of randomized controlled trials as verified by abstract author.

Comparisons
  • Proportion of abstracts published

  • Cumulative proportion of abstracts published

  • 'Positive' versus not 'positive'

  • Sample size equal to or above the median versus sample size below the median

  • Multi‐centered versus single center

  • 'High' versus 'low' quality as defined by author

Outcomes
  • 61 of 93 abstracts published

  • Proportion of abstracts published by time

    • Cumulative proportion of abstracts published at 48 months showed proportion published = 63.4% (59/93 abstracts)

  • Factors related to proportion of abstracts published included

    • 33/46 'positive' (defined as significant results) versus 28/47 not 'positive' abstract results published

    • 31/43 abstracts with sample size equal to or above the median versus 24/42 abstracts with sample size below the median

    • 14/19 abstracts with multiple centers versus 45/71 abstracts with a single center published

    • 31/43 abstracts rated by author as 'high' quality versus 29/47 abstracts rated as 'low' quality published

Notes
  • Ophthalmology/optometry ‐ ophthalmology

  • Government funding

Risk of bias
Item Authors' judgement Description
Sampling method? Yes Included all abstracts that described specific study design, so low risk of bias.
Search for publications? Yes Searched 1 database and contacted abstract authors.
Follow‐up time? Yes The meeting in 1988 had 48 months and the meeting in 1989 only 36 months follow‐up.
Matching? Yes Matched by 2 different criteria.
Adjustment for confounding? No Examined association of positive results, sample size, trial design, multi‐center status, abstract quality, and subspecialty with publication using stratified analysis and Chi2 tests.