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. 2018 Nov 20;2018(11):MR000005. doi: 10.1002/14651858.MR000005.pub4

Toma 2006.

Methods Identification of subsequent full‐length publications
  • Searched electronic database

    • MEDLINE, PubMed, Embase, Cochrane Central Register of Controlled Trials, Google/Google Scholar, SIGLE, CardioSource, Incirculation to December 2005

    • Search completed by investigator

    • Searched by all authors, keywords, title, and study acronym

    • Matched abstract to full‐length publication by

      • Authors

      • Study name/acronym

      • Title keyword

Data
  • Included 186 abstracts presented at the 1999 to 2002 American College of Cardiology scientific meetings

  • Included 86 abstracts of late breaking RCTs reporting clinical outcomes, and 100 other randomly chosen RCTs; RCTs with non‐human participants were excluded

Comparisons
  • Proportion of abstracts published, overall and by meeting

  • Median time to publication by whether 'late‐breaking' or not

  • Survival analysis of publication rate

  • 'Positive' versus not 'positive'

  • Multi‐centered versus single center

  • 'Late‐breaking' versus not 'late‐breaking'

Outcomes
  • 148 of 186 abstracts published

  • 34/43 abstracts presented at the 1999 meeting, 36/48 at the 2000 meeting, 41/49 at the 2001 meeting, and 38/46 at the 2002 meeting published

  • Proportion of abstracts published by time

    • Median time to publication = 11.5 months for 'late‐breaking' abstracts

    • Median time to publication = 22 months for abstracts that were not 'late‐breaking'

    • Survival analysis of proportion published at 60 months = 83.3%

  • Factors related to proportion of abstracts published included

    • 70/84 'positive' (defined as significant results) versus 78/102 not 'positive' abstract results published

    • 74/93 'positive' (defined as experimental better than control) versus 74/93 not 'positive' abstract results published

    • 55/63 abstracts with multiple centers versus 93/123 abstracts with a single center published

    • 79/86 'late‐breaking' abstracts versus 69/100 abstracts that were not 'late‐breaking' published

Notes
  • Cardiology

  • Reported receiving no funding

Risk of bias
Item Authors' judgement Description
Sampling method? Yes Included a random selection of abstracts describing RCTs and al late breaking abstracts describing RCTs.
Search for publications? Yes Searched 7 databases.
Follow‐up time? Yes All meetings before 2002 had at least 48 months follow‐up. The meeting in 2002 only had 36 months follow‐up.
Matching? Yes Matched by 3 different criteria.
Adjustment for confounding? Yes Examined association of positive results, multi‐center status, and 'late‐breaking' status with publication using Chi2 or tests and time to publication using a multivariable proportional hazards analysis.