Table 1:
Characteristics of overall, serous/poorly differentiated (PD) and endometrioid/clear cell (CC) ovarian cancer (OC) cases, rapidly fatal tumors, and all controls at time of blood collection.
| All Controls (N = 252) |
Overall OC (N = 252) |
Serous/PD OC (N = 176) |
Endometrioid/CC OC (N = 34) |
Other histotypes (N = 42) |
Rapidly fatal tumors (N=86) |
|
|---|---|---|---|---|---|---|
| Mean (SD) | ||||||
| Age at blood draw* | 55.6 (7.8) | 55.5 (7.9) | 55.3 (7.9) | 54.0 (8.1) | 57.8 (7.5) | 58.5 (6.8) |
| BMI at blood draw | 24.7 (4.1) | 25.0 (4.7) | 24.5 (4.2) | 26.9 (5.8) | 25.5 (5.4) | 25.3 (5.3) |
| Time to diagnosis (years) | - | 12.3 (5.2) | 12.8 (5.3) | 12.1 (5.1) | 10.9 (4.7) | 12.7 (5.2) |
| Age at diagnosis (years) | - | 69.7 (9.7) | 68.1 (9.8) | 66.0 (9.8) | 68.7 (9.2) | 71.2 (8.7) |
| N (Percent) | ||||||
| Tumor morphology | ||||||
| Invasive | - | 227 (90) | 163 (93) | 33 (97) | 31 (74) | 86 (100) |
| Borderline | - | 22 (9) | 13 (7) | 1 (3) | 8 (19) | 0 (0) |
| Unknown | - | 3 (1) | 0 (0) | 0 (0) | 3 (7) | 0 (0) |
| Menopausal status blood draw* | ||||||
| Premenopausal | 82 (33) | 82 (33) | 56 (32) | 16 (47) | 10 (24) | 14 (16) |
| Postmenopausal, No HT use | 71 (28) | 68 (27) | 47 (27) | 5 (15) | 16 (38) | 29 (34) |
| Postmenopausal, HT use | 66 (26) | 69 (27) | 48 (27) | 8 (24) | 13 (31) | 34 (40) |
| Unknown | 33 (13) | 33 (13) | 25 (14) | 5 (15) | 3 (7) | 9 (10) |
| Cohort* | ||||||
| NHS | 212 (84) | 212 (84) | 147 (84) | 27 (79) | 38 (90) | 79 (92) |
| Race | ||||||
| White | 251 (100) | 251 (100) | 175 (100) | 34 (100) | 42 (100) | 86 (100) |
| Oral contraceptive use duration | ||||||
| None or <3 months | 123 (49) | 118 (47) | 81 (46) | 18 (53) | 19 (45) | 48 (56) |
| 3 months to 3 years | 33 (13) | 32 (13) | 22 (12) | 3 (9) | 7 (17) | 10 (12) |
| 3 to 5 years | 45 (18) | 63 (25) | 46 (26) | 8 (24) | 9 (21) | 16 (19) |
| 5+ years | 51 (20) | 39 (15) | 27 (15) | 5 (15) | 7 (17) | 12 (14) |
| Parity | ||||||
| No children | 12 (5) | 24 (10) | 16 (9) | 5 (15) | 3 (7) | 7 (8) |
| 1 child | 11 (4) | 13 (5) | 8 (5) | 1 (3) | 4 (10) | 2 (2) |
| 2 children | 72 (29) | 89 (35) | 60 (34) | 15 (44) | 14 (33) | 23 (27) |
| 3 children | 77 (31) | 65 (26) | 45 (26) | 9 (26) | 11 (26) | 25 (29) |
| 4+ children | 80 (32) | 61 (24) | 47 (27) | 4 (12) | 10 (24) | 29 (34) |
| Tubal ligation | ||||||
| Yes | 43 (17) | 39 (15) | 30 (17) | 5 (15) | 34 (10) | 17 (20) |
*
matching factors; HT any type of hormone therapy