Table 2: Odds ratio (OR) for an increase from the 10th to the 90th percentile of metabolite levels and 95% confidence intervals (CI) of associations with risk of overall, serous/poorly differentiated and endometrioid/clear cell ovarian cancer.
Results with p-values ≤0.01 are shown for overall and serous/poorly differentiated ovarian cancer. The top 10 (out of 30) metabolites with p-values ≤0.01 are shown for endometrioid/clear cell tumors. Complete results are available in Supplementary Tables 1-2.
| A Overall Ovarian Cancer (N = 252 cases and 252 controls) | ||||
|---|---|---|---|---|
| HMDB ID | Metabolite | OR (95% CI) | P-value | Adjusted P-value |
| HMDB00767 | pseudouridine | 2.56 (1.48-4.45) | 0.001 | 0.150 |
| HMDB01348 | C18:0 SM | 2.10 (1.26-3.49) | 0.004 | 0.570 |
| HMDB03681 | 4-acetamidobutanoate | 2.10 (1.24-3.56) | 0.006 | 0.672 |
| HMDB05398* | C56:4 TAG | 2.03 (1.21-3.39) | 0.007 | 0.722 |
| HMDB05380* | C52:5 TAG | 1.96 (1.20-3.20) | 0.007 | 0.733 |
| HMDB05923 | N4-acetylcytidine | 1.88 (1.18-3.02) | 0.008 | 0.772 |
| HMDB10169 | C16:0 SM1 | 2.06 (1.19-3.56) | 0.009 | 0.807 |
| -- | armillane2 | 0.49 (0.28-0.85) | 0.010 | 0.824 |
| B Serous/Poorly differentiated ovarian cancer (N = 176 cases and 252 controls) | ||||
| HMDB ID | Metabolite | OR (95% CI) | P-value | Adjusted P-value |
| HMDB00767 | pseudouridine | 2.38 (1.33-4.32) | 0.004 | 0.552 |
| HMDB05380* | C52:5 TAG | 2.09 (1.23-3.59) | 0.007 | 0.745 |
| HMDB05363* | C52:4 TAG | 2.03 (1.21-3.47) | 0.008 | 0.809 |
| HMDB05391* | C54:6 TAG-A | 1.99 (1.18-3.38) | 0.010 | 0.862 |
| HMDB05385* | C54:5 TAG | 1.99 (1.19-3.39) | 0.010 | 0.851 |
| C Endometrioid/Clear cell ovarian cancer (N = 34 cases and 252 controls) | ||||
| HMDB ID | Metabolite | OR (95% CI) | P-value | Adjusted P-value |
| HMDB11243* | C36:2 PC plasmalogen | 0.11 (0.03-0.35) | 0.0003 | 0.056 |
| HMDB00767 | pseudouridine | 9.84 (2.89-37.82) | 0.0004 | 0.072 |
| HMDB05462* | C56:7 TAG | 5.85 (2.04-18.02) | 0.001 | 0.236 |
| HMDB00201 | C2 carnitine | 7.4 (2.37-25.35) | 0.001 | 0.143 |
| HMDB05392* | C56:8 TAG | 5.75 (2.00-17.72) | 0.002 | 0.260 |
| HMDB01999 | eicosapentaenoate | 6.25 (2.05-20.65) | 0.002 | 0.286 |
| HMDB11208* | C34:1 PC plasmalogen-A | 0.18 (0.05-0.54) | 0.003 | 0.468 |
| HMDB07103* | C34:2 DAG | 4.46 (1.64-12.85) | 0.004 | 0.577 |
| HMDB11520 | C22:0 LPE | 0.21 (0.07-0.59) | 0.004 | 0.517 |
| HMDB02183 | docosahexaenoate | 5.49 (1.74-18.72) | 0.005 | 0.617 |
*
representative ID
--
HMBD ID not available
1
significantly associated with risk in our analysis of lipid-related metabolites and risk of ovarian cancer (manuscript in revision)
2
preliminary ID