Table 3:

P-values, FDR, odds ratio (OR) for an increase from the 10^th to the 90^th percentile of metabolite levels and 95% confidence intervals (CI) of WGCNA metabolite modules associated with risk of ovarian cancer overall and by histotype.

	Overall OC				Serous/PD OC				Endometrioid/CC OC
Module / number of metabolites	OR (95% CI)	P-value	FDR	explained variance [%]	OR (95% CI)	P-value	FDR	explained variance [%]	OR (95% CI)	P-value	FDR	explained variance [%]
M1 / 24	1.99 (1.15-3.42)	0.013	0.072	14.51	1.64 (0.89-3.05)	0.114	0.46	14.87	1.09 (0.38-3.11)	0.875	0.613	14.62
M2 / 79	1.62 (0.92-2.85)	0.093	0.186	23.63	1.16 (0.65-2.07)	0.624	0.701	23.35	6.14 (1.97-20.67)	0.002	0.011	24.54
M3 / 76	0.9 (0.56-1.46)	0.678	0.682	65.22	1.06 (0.62-1.8)	0.839	0.839	65.18	0.48 (0.17-1.28)	0.151	0.212	66.23
M4 / 74	0.5 (0.28-0.9)	0.022	0.072	17.86	0.64 (0.35-1.15)	0.138	0.46	18.13	0.17 (0.05-0.54)	0.003	0.011	17.63
M5 / 49	0.91 (0.56-1.46)	0.682	0.682	24.23	1.2 (0.71-2.03)	0.49	0.701	23.94	0.35 (0.12-0.94)	0.041	0.072	21.61
M6 / 37	1.56 (0.95-2.58)	0.081	0.186	40.38	1.17 (0.68-2.01)	0.575	0.701	40.32	1.4 (0.5-3.99)	0.522	0.456	40.16
M7 / 32	1.8 (1.12-2.88)	0.015	0.072	32.45	1.97 (1.17-3.36)	0.012	0.117	32	1.94 (0.71-5.5)	0.203	0.237	32.69
M8 / 24	0.82 (0.49-1.37)	0.441	0.552	65.98	0.81 (0.47-1.4)	0.451	0.701	65.34	0.22 (0.07-0.65)	0.007	0.017	64.15
M9 / 14	0.73 (0.45-1.19)	0.205	0.341	37.33	0.88 (0.51-1.5)	0.631	0.701	38.1	0.79 (0.29-2.21)	0.651	0.506	36.26
M10 / 11	0.75 (0.43-1.29)	0.293	0.419	46.53	0.7 (0.38-1.29)	0.257	0.644	45.92	1.88 (0.57-6.46)	0.305	0.305	47.51