Table 3.

Most Common (≧ 10% in Non-Hematologic) Toxicities Summary (maximum grade shown), in Cycle 1.

Dose Level and Toxicity Grade, No. (%)
	All Dose Levels (n=27)		Dose level 1 (n=3)		Dose level 2 (n=3)		Dose level 3 (n=3)		Dose level 4 (n=12)		Dose level 5 (n=6)
Toxicity Type	All grades	≧Grade 3	All grades	≧Grade 3	All grades	≧Grade 3	All grades	≧Grade 3	All grades	≧Grade 3	All grades	≧Grade 3
GI TOXICITY
Diarrhea	24 (89)	3 (11)	3 (100)	1 (33)	3 (100)		3 (100)		9 (75)		6 (100)	2 (33)
Vomiting	13 (48)	1 (4)	1 (33)		2 (67)		2 (67)		4 (33)		4 (67)	1 (17)
Nausea	12 (44)	1 (4)	1 (33)		2 (67)		2 (67)		4 (33)		3 (50)	1 (17)
BONE MARROW TOXICITY
Lymphocyte count decreased	18 (67)	6 (22)	2 (67)		1 (33)		3 (100)	1 (33)	9 (75)	5 (42)	3 (50)
Anemia	15 (56)	1 (4)	1 (33)		1 (33)		2 (67)		8 (67)	1 (8)	3 (50)
White blood cell decreased	12 (44)	3 (11)	2 (67)				2 (67)	1 (33)	5 (42)	2 (17)	3 (50)
Neutrophil count decreased	9 (33)	6 (22)					2 (67)	2 (67)	5 (42)	2 (17)	2 (33)	2 (33)
OTHER
Hypotension	1 (4)	1 (4)									1 (17)	1 (17)
INVESTIGATIONS
Hypophosphatemia	7 (26)	1 (4)			2 (67)				4 (33)		1 (17)	1 (17)
Hypokalemia	6 (22)	2 (7)							3 (25)	1 (8)	3 (50)	1 (17)