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. Author manuscript; available in PMC: 2021 Mar 6.
Published in final edited form as: J Mol Biol. 2019 Oct 16;432(5):1514–1534. doi: 10.1016/j.jmb.2019.09.016

Figure 5: Effects of glucose on intracellular lipid metabolism in the β-cell.

Figure 5:

In the presence of simultaneously elevated levels of glucose and FFAs, the increase in cytosolic malonyl-CoA resulting from glucose metabolism inhibits carnitine-palmitoyl transferase 1 (CPT-1). Transport of long-chain acyl-CoA (LC-CoA) in the mitochondria is blocked, and FFA metabolism is diverted towards the synthesis of lipid-derived signaling molecules such as sphingolipids, diacylglycerols (DG), phosphatidic acid (PA), phospholipids (PL) and triacylglycerols (TG). Adapted from [51] with permission.