4.1. Analysis.
Comparison 4 Other antiemetic comparisons, Outcome 1 Complete control of acute nausea.
| Complete control of acute nausea | ||||||
|---|---|---|---|---|---|---|
| Study | Antiemetic 1 | Antiemetic 2 | Number receiving antiemetic 1 | Number receiving antiemetic 2 | Relative risk of complete control of acute nausea | (95% confidence interval) |
| Brock 1996 | Ondansetron 5 mg/m² IV over 15 minutes immediately prior to chemotherapy, then at +8 hours and +16. Ongoing ondansetron given orally < 1 m² 4 mg TDS, > 1 m² 8 mg TDS, continued for 3 days after last day of chemotherapy or 5 days if nausea and vomiting persisted | Ondansetron 10 mg/m² IV over 15 minutes immediately prior to chemotherapy, then 5 mg/m² IV at +8 hours and +16. Ongoing ondansetron given orally < 1 m² 4 mg TDS, > 1 m² 8 mg TDS, continued for 3 days after last day of chemotherapy or 5 days if nausea and vomiting persisted | 79 patients | 80 patients | 1.01 | 0.81 to 1.25 |
| Ekert 1979 | Tetrahydrocannabinol (THC) 10 mg/m², given at ‐2, 4, 8, 16 and 24 hours around chemotherapy administration | Metoclopramide 5 mg (for < 0.7 m² patients) or 10 mg (for > 0.7 m² patients) at ‐2, 8, 16 and 24 hours. Placebo given at +4 hours | 17 episodes | 25 episodes | 3.53 | 2.28 to 5.46 |
| Ekert 1979a | Tetrahydrocannabinol (THC) 10 mg/m2, given at ‐2, 4, 8, 16 and 24 hours around chemotherapy administration | Prochlorperazine ‐ tablets. Weight based schedule, using surface area (SA) 0.7 to 1.1 m² 20 mg/day divided, SA 1.1 to 1.4 m² 30 mg/day divided, SA > 1.1 m² 40 mg/day divided | 18 episodes | 18 episodes | 20.7 | 17.2 to 36.2 |
| Mehta 1986 | Methylprednisolone 4 mg/kg IV 30 minutes prior to chemo | Chlorpromazine 0.5 mg/kg IV 30 minutes prior to chemotherapy | 10 patients | 10 patients | 0.75 | 0.44 to 1.25 |
| Noguera 2001 | Ondansetron 0.45 mg/kg IV 15 minutes after chemotherapy | Tropisetron 0.20 mg/kg IV 15 minutes after chemotherapy | 29 episodes | 20 episodes | 0.97 | 0.54 to 1.69 |
| Sandoval 1999 | Ondansetron 0.6 mg/kg (max 32 mg) IV over 30 minutes before chemotherapy | Ondansetron 0.15 mg/kg (max 8 mg) IV over 30 minutes before chemotherapy then every 4 hours for a total of 4 doses | 16 patients | 15 patients | 1.25 | 0.70 to 2.22 |
| Suarez 1994 | Placebo, or tropisetron (0.05 mg/kg) given as single dose | Placebo, or tropisetron (0.1 to 0.4 mg/kg) given as single dose | 26 patients | 18 patients | 0.98 | 0.54 to 1.74 |