4.5. Analysis.
Comparison 4 Other antiemetic comparisons, Outcome 5 Other nausea &/or vomiting outcomes.
| Other nausea &/or vomiting outcomes | |||||||
|---|---|---|---|---|---|---|---|
| Study | Antiemetic 1 | Antiemetic 2 | Number receiving antiemetic 1 | Number receiving antiemetic 2 | Adverse outcome in patients/episodes receiving antiemetic 1 | Adverse outcome in patients/episodes receiving antiemetic 2 | Outcome details & notes |
| Dalzell 1986 | Nabilone 0.5 mg BD if < 18 kg, 1 mg BD if 18 to 36 kg, 1mg TDS if > 36 kg | Domperidone 5 mg TDS if < 18 kg, 10 mg TDS if 18 to 36 kg, 15 mg TDS if > 36 kg | 18 episodes | 18 episodes | 1.5 | 2.5 | Mean severity score (0 = nil, 3 = worst), P = 0.001 by Wilcoxon sign‐rank test |
| Graham‐Pole 1986 | Metoclopramide 0.5 mg/kg/dose IV | Chlorpromazine 0.5 mg/kg/dose IV | 24 patients | 26 patients | 3.5 (SD 4.1) | 1.8 (SD 2.3) | Mean number of vomits in first 24hrs |
| Hahlen 1995 | Granisetron 20 mcg/kg IV | Dexamethasone 2 mg/m²m2 IV plus Chlorpromazine 0.5 mg/kg IVI | 46 patients | 42 patients | 1.5 | 7 | Median number of vomits in first 24hrs, P = 0.001 by Wilcoxon sign‐rank test |
| Mehta 1986 | Methylprednisolone 4 mg/kg IV 30 minutes prior to chemotherapy | Chlorpromazine 0.5 mg/kg IV 30 minutes prior to chemotherapy | 10 patients | 10 patients | 10.9h (SD 3.3h) | 3.2h (SD 3.1h) | Mean duration of nausea |
| Nagel 2008 | Ondansetron (0.15 mg/kg) prior to anaethesia and intrathecal methotrexate administration | Placebo | 29 patients | 31 patients | 2 | 0.5 | Mean number of vomits (no SD given, p<0.001, graph extracted, in 24h post procedure) |
| Orchard 1999 | Granisetron: 10 mcg/kg/dose before start of chemotherapy/TBI then every 12 hours | Ondansetron: loading dose 0.15 mg/kg before start of chemotherapy/TBI then continuous infusion 0.03 mg/kg/h rounded to nearest 0.1 mg (until day of transplant ‐ day 0) | 23 patients | 28 patients | 0.82 (0.55 to 1.09) | 1.14 (0.90 to 1.38) | Mean nausea score (0 = nil, 5 = worst) (95% CI) |
| Orchard 1999 | Granisetron: 10 mcg/kg/dose before start of chemotherapy/TBI then every 12 hours | Ondansetron: loading dose 0.15 mg/kg before start of chemotherapy/TBI then continuous infusion 0.03 mg/kg/h rounded to nearest 0.1 mg (until day of transplant ‐ day 0) | 23 patients | 28 patients | 0.54 (0.27 to 0.81) | 0.87 (0.63 to 1.11) | Mean number of vomits in first 24 hours (95% CI) |