Complete control of acute vomiting
Study	Antiemetic 1	Antiemetic 2	Number assessed antiemetic 1	Number assessed antiemetic 2	Relative risk of complete control of acute vomiting	(95% confidence interval)
Alvarez 1995	Ondansetron, IV, 0.15 mg/kg 30 minutes prior to chemotherapy, then BD on chemotherapy for 1 to 5 days plus dexamethasone either 4 mg/m² QDS or 8 mg/m² BD (depended on institution)	Ondansetron, IV, 0.15 mg/kg 30 minutes prior to chemotherapy, then BD on chemo for 1 to 5 days	30 episodes	30 episodes	2.43	1.76 to 3.34
Basade 1996	Dexamethasone 8 mg/m² IV 15 minutes prior to chemotherapy	Metoclopramide 1.5 mg/kg IV 15 minutes prior to chemotherapy	53 episodes	52 episodes	2.10	1.77 to 2.50
Berrak 2007	Granisetron 10 mcg/kg IV 30 minutes prior to Rx	Granisetron 40 mcg/kg IV 30 minutes prior to Rx	104 episodes	121 episodes	0.88	0.70 to 1.10
Brock 1996	Ondansetron 5 mg/m² IV over 15 minutes immediately prior to chemotherapy, then at +8 hours and +16. Ongoing ondansetron given orally < 1 m² 4 mg TDS, > 1 m² 8 mg TDS, continued for 3 days after last day of chemotherapy or 5 days if nausea and vomiting persisted.	Ondansetron 10 mg/m² IV over 15 minutes immediately prior to chemotherapy, then 5 mg/m² IV at +8 hours and +16. Ongoing ondansetron given orally < 1 m² 4 mg TDS, > 1 m² 8 mg TDS, continued for 3 days after last day of chemotherapy or 5 days if nausea and vomiting persisted.	79 patients	79 patients	0.89	0.72 to 1.10
Chan 1987	Nabilone orally (capsules) starting 8 to 12 hours prior to chemotherapy and repeated 2 or 3 times a day according to dosage schedule	Prochlorperazine orally (capsules) starting 8 to 12 hours prior to chemotherapy and repeated 2 or 3 times a day according to dosage schedule	30 episodes	30 episodes	1.00	0.85 to 1.17
Dick 1995	Ondansetron 3 to 8 mg/m² given pre‐chemotherapy, then BD initially IV then orally for 3 days	Metoclopramide 10 mg/m² IV QDS for 3 days, with 2.5 mg procyclidine. Dexamethasone 4 mg/m² IV then 2 mg/m² TDS IV or PO	15 patients	15 patients	3.67	2.25 to 5.98
Ekert 1979	Tetrahydrocannabinol (THC) 10 mg/m², given at ‐2, 4, 8, 16 and 24 hours around chemotherapy administration	Metoclopramide 5 mg (for < 0.7 m² patients) or 10 mg (for > 0.7 m² patients) at ‐2, 8, 16 and 24 hours. Placebo given at +4 hours	17 episodes	25 episodes	3.53	2.28 to 5.46
Ekert 1979a	Tetrahydrocannabinol (THC) 10 mg/m², given at ‐2, 4, 8, 16 and 24 hours around chemotherapy administration	Prochlorperazine ‐ tablets. Weight based schedule SA 0.7 to 1.1 m² 20 mg/day divided, SA 1.1 to 1.4 m² 30 mg/day divided, SA > 1.1 m² 40 mg/day divided	18 episodes	18 episodes	19.00	13.71 to 26.33
Hirota 1993	Granisetron 40 mcg/kg IV 30 minutes prior to Rx plus methylprednisolone 10 mg/kg (max 500mg) IV	Granisetron 40 mcg/kg IV 30 minutes prior to Rx	20 episodes	20 episodes	1.60	1.03 to 2.48
Marshall 1989	Cocktail. Metoclopramide 2 mg/kg/dose 0, 2, 6, 12 hours. Dex 0.7 mg/kg 0 hours. Benztropine 0.02 mg/kg/dose 0, 6 hours. Lorazepam 0.05 mg/kg/dose ‐1 hour and 12 hours (PO ‐ rest IV)	Chlorpromazine 0.825 mg/kg QDS IV for 4 doses	26 episodes	26 episodes	2.40	1.76 to 3.27
Mehta 1986	Methylprednisolone 4 mg/kg IV 30 minutes prior to chemo	Chlorpromazine 0.5 mg/kg IV 30 minutes prior to chemotherapy	10 patients	10 patients	1.00	0.54 to 1.86
Parker 2001	Placebo (saline) IV 15‐minute infusion 30 minutes prior to lumbar puncture	Low‐dose ondansetron 0.15 mg/kg IV 15‐minute infusion 30 minutes prior to lumbar puncture	51 episodes	47 episodes	0.51	0.38 to 0.69
Safonova 1999	Ondansetron 8 mg PO BD plus 4 to 8 mg dexamethasone IV	Ondansetron 5 mg/m² IV BD plus 4 to 8 mg dexamethasone IV	26 patients	26 patients	1.04	0.62 to 1.75
Sandoval 1999	Ondansetron 0.6 mg/kg (max 32 mg) IV over 30 minutes before chemotherapy.	Ondansetron 0.15 mg/kg (max 8 mg) IV over 30 minutes before chemotherapy then every 4 hours for a total of 4 doses	16 patients	15 patients	0.94	0.49 to 1.79
Suarez 1994	Placebo, or tropisetron (0.05 mg/kg) given as single dose	Placebo, or tropisetron (0.1 to 0.4 mg/kg) given as single dose	23 patients	18 patients	0.89	0.51 to 1.54