Emir 2013.

Methods	RCT Cross‐over
Participants	Paediatric patients (age 1 to 16 years, median 7 years; 13/23 male) receiving cisplatin‐containing chemotherapy regimens
Interventions	Granisetron 0.04 mg/kg plus dexamethasone 0.2 mg/kg Granisetron 0.04 mg/kg, dexamethasone 0.2 mg/kg, midazolam 0.04 mg/kg, and diphenhydramine 2.5 mg/kg
Outcomes	Number of vomits Severity of nausea (no definition of how this was defined given in paper) Use of rescue therapy Adverse events Complete response was defined as no nausea or vomiting, partial response as 1 or 2 vomits but no need for rescue therapy, no response as more than 3 emetic episodes or need for rescue therapy
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding (performance bias and detection bias) Acute nausea	Unclear risk	Not stated
Blinding (performance bias and detection bias) Acute vomiting	Unclear risk	Not stated
Blinding (performance bias and detection bias) Other outcomes	Unclear risk	Not stated
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants accounted for in results
Selective reporting (reporting bias)	Low risk	All outcomes reported
Other bias	Unclear risk	Paired data not provided