Hirota 1993.

Methods	RCT Cross‐over
Participants	Any paediatric malignancy: osteosarcoma (2), NHL (3), "brain tumour" (2), ALL (2), other sarcoma (3) Any chemotherapy protocol that was moderate or highly emetogenic, with 2 courses required (for cross‐over) Mean age 10.8 years (4 to 18 years), 8/12 were male
Interventions	Granisetron 40 mcg/kg IV 30 minutes prior to Rx Granisetron 40 mcg/kg IV 30 minutes prior to Rx plus methylprednisolone 10 mg/kg (max 500 mg) IV
Outcomes	Parents reported vomiting episodes
Notes	Paired data
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding (performance bias and detection bias) Acute nausea	Unclear risk	Not stated
Blinding (performance bias and detection bias) Acute vomiting	Unclear risk	Not reported
Blinding (performance bias and detection bias) Other outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	High risk	2 participants did not complete cross‐over. Data not given
Selective reporting (reporting bias)	Low risk	—
Other bias	Low risk	No other risk of bias noted