Mehta 1997.

Methods	RCT
Participants	28 participants with need for stem cell (bone marrow) transplantation (allograft or autologous), including those receiving TBI. Median age 8 years (range 4 to 12 years), 9/15 male in ondansetron group. Median age 9.5 years (range 4 to 17), 9/13 male in perphenazine group.
Interventions	15 participants received ondansetron loading 0.15 mg/kg then 0.45 mg/kg as continuous infusion 13 participants received perphenazine 0.06 mg/kg loading and 0.4 mg/kg per 24 hours continuous infusion), plus diphenhydramine 1 mg/kg QDS
Outcomes	"Continuous" recording of vomiting and retching (events within 5 minutes considered as a single episode). Probably nursing staff recording outcomes
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding (performance bias and detection bias) Acute nausea	High risk	Not reported
Blinding (performance bias and detection bias) Acute vomiting	High risk	Not reported
Blinding (performance bias and detection bias) Other outcomes	High risk	Blinding of care provider: no Blinding of participant: no Blinding of outcome assessors: no
Incomplete outcome data (attrition bias) All outcomes	High risk	3 not evaluated, unclear from which arm or even if excluded prior to randomisation
Selective reporting (reporting bias)	Low risk	—
Other bias	Low risk	No other risk of bias noted