Siddique 2011.

Methods	RCT
Participants	60 children aged 4 to 11 scheduled to receive high‐dose methotrexate
Interventions	30 received ondansetron 4 mg 30 received granisetron 1 mg
Outcomes	Modified MANE scale (self reported occurrence of nausea, retching, or vomiting) Requirement of additional dose of antiemetic Side effects
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Stratified using random sampling
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding (performance bias and detection bias) Acute nausea	Low risk	Double blind
Blinding (performance bias and detection bias) Acute vomiting	Low risk	Double blind
Blinding (performance bias and detection bias) Other outcomes	Low risk	Double blind
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants accounted for
Selective reporting (reporting bias)	Low risk	All outcomes reported
Other bias	Low risk	No other risk of bias noted