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. 2013 Jul 31;2013(7):CD001449. doi: 10.1002/14651858.CD001449.pub3

Comparison 2. Calcium channel blockers versus hydralazine.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Persistent high blood pressure 6 313 Risk Ratio (M‐H, Fixed, 95% CI) 0.37 [0.21, 0.66]
1.1 Nifedipine versus hydralazine 5 273 Risk Ratio (M‐H, Fixed, 95% CI) 0.38 [0.21, 0.70]
1.2 Isradipine versus hydralazine 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 0.25 [0.03, 2.05]
2 Hypotension 4 249 Risk Ratio (M‐H, Fixed, 95% CI) 2.92 [0.32, 26.90]
2.1 Nifedipine versus hydralazine 3 209 Risk Ratio (M‐H, Fixed, 95% CI) 2.92 [0.32, 26.90]
2.2 Isradapine versus hydralazine 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 Further episode/s of very high blood pressure 2 163 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.65, 1.11]
3.1 Nifedipine versus hydralazine 2 163 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.65, 1.11]
3.2 Isradipine versus hydralazine 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 Side‐effects for the woman 5 286 Risk Ratio (M‐H, Fixed, 95% CI) 0.81 [0.52, 1.25]
4.1 Nifedipine versus hydralazine 4 246 Risk Ratio (M‐H, Fixed, 95% CI) 0.81 [0.52, 1.25]
4.2 Isradipine versus hydralazine 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Side‐effects for the woman (specific effects) 5   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
5.1 Palpatations 2 87 Risk Ratio (M‐H, Random, 95% CI) 0.63 [0.28, 1.39]
5.2 Nausea and/or vomiting 4 170 Risk Ratio (M‐H, Random, 95% CI) 1.72 [0.27, 10.81]
5.3 Headache 5 296 Risk Ratio (M‐H, Random, 95% CI) 1.14 [0.43, 3.02]
5.4 Flushing 4 170 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.15, 7.51]
5.5 Dyspnoea 1 37 Risk Ratio (M‐H, Random, 95% CI) 0.85 [0.06, 12.59]
6 Caesarean section 1 37 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.56, 1.29]
6.1 Nifedipine versus hydralazine 1 37 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.56, 1.29]
7 Fetal or neonatal death 4 161 Risk Ratio (M‐H, Fixed, 95% CI) 1.36 [0.42, 4.41]
7.1 Nifedipine versus hydralazine 3 120 Risk Ratio (M‐H, Fixed, 95% CI) 1.48 [0.40, 5.48]
7.2 Isradapine versus hydralazine 1 41 Risk Ratio (M‐H, Fixed, 95% CI) 0.95 [0.06, 14.22]
8 Apgar < 7 at 5 minutes 1 50 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Fetal heart rate decelerations 4 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.38 [0.11, 1.31]
9.1 Nifedipine versus hydralazine 3 213 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.04, 2.99]
9.2 Isradipine versus hydralazine 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 0.4 [0.09, 1.83]