Comparison 2. Calcium channel blockers versus hydralazine.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Persistent high blood pressure	6	313	Risk Ratio (M‐H, Fixed, 95% CI)	0.37 [0.21, 0.66]
1.1 Nifedipine versus hydralazine	5	273	Risk Ratio (M‐H, Fixed, 95% CI)	0.38 [0.21, 0.70]
1.2 Isradipine versus hydralazine	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.25 [0.03, 2.05]
2 Hypotension	4	249	Risk Ratio (M‐H, Fixed, 95% CI)	2.92 [0.32, 26.90]
2.1 Nifedipine versus hydralazine	3	209	Risk Ratio (M‐H, Fixed, 95% CI)	2.92 [0.32, 26.90]
2.2 Isradapine versus hydralazine	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Further episode/s of very high blood pressure	2	163	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.65, 1.11]
3.1 Nifedipine versus hydralazine	2	163	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.65, 1.11]
3.2 Isradipine versus hydralazine	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Side‐effects for the woman	5	286	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.52, 1.25]
4.1 Nifedipine versus hydralazine	4	246	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.52, 1.25]
4.2 Isradipine versus hydralazine	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Side‐effects for the woman (specific effects)	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Palpatations	2	87	Risk Ratio (M‐H, Random, 95% CI)	0.63 [0.28, 1.39]
5.2 Nausea and/or vomiting	4	170	Risk Ratio (M‐H, Random, 95% CI)	1.72 [0.27, 10.81]
5.3 Headache	5	296	Risk Ratio (M‐H, Random, 95% CI)	1.14 [0.43, 3.02]
5.4 Flushing	4	170	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.15, 7.51]
5.5 Dyspnoea	1	37	Risk Ratio (M‐H, Random, 95% CI)	0.85 [0.06, 12.59]
6 Caesarean section	1	37	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.56, 1.29]
6.1 Nifedipine versus hydralazine	1	37	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.56, 1.29]
7 Fetal or neonatal death	4	161	Risk Ratio (M‐H, Fixed, 95% CI)	1.36 [0.42, 4.41]
7.1 Nifedipine versus hydralazine	3	120	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [0.40, 5.48]
7.2 Isradapine versus hydralazine	1	41	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.06, 14.22]
8 Apgar < 7 at 5 minutes	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
9 Fetal heart rate decelerations	4	253	Risk Ratio (M‐H, Fixed, 95% CI)	0.38 [0.11, 1.31]
9.1 Nifedipine versus hydralazine	3	213	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.04, 2.99]
9.2 Isradipine versus hydralazine	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.4 [0.09, 1.83]