France 2010.
Methods | Described as a “Preliminary randomized controlled trial”. France. | |
Participants | 18 women with severe PE without previous antihypertensive treatment. The therapeutic goal was control BP to a mean BP of between 105 and 125 mmgHg. | |
Interventions | Urapidil 6.25 mg boluses every 5 mins until the DBP dropped below 105 mmHg followed by a 4 mg/hr infusion as needed (n = 9). Nicardipine 1 µ/kg/min infusion until a 15% reduction in mean BP, followed by a 0.75 µ/kg/min infusion adjusted as needed (n = 9). |
|
Outcomes | Achievement of BP goal in 2 hrs or less; number of episodes of hypotension (MBP below 100 mmHg); maternal and neonatal side‐effects. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | No details, available as abstract only. |
Allocation concealment (selection bias) | Unclear risk | No details, available as abstract only. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Different regimens. |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Different regimens. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | All main outcomes reported for all women, but there was 1 protocol deviation. |
Selective reporting (reporting bias) | Unclear risk | No details, available as abstract only. |
Other bias | Unclear risk | No details, available as abstract only. |