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. 2013 Jul 31;2013(7):CD001449. doi: 10.1002/14651858.CD001449.pub3

Mexico 1989.

Methods 'Randomised', no further information. 5 women excluded from chlorpromazine group because they received another antihypertensive. CFU ‐ B, blinding C.
Participants 60 women with severe PE or eclampsia. Excluded if cardiopathy, diabetes, isoimmunisation, twin pregnancy, or antihypertensive in 48 hr before trial entry.
Interventions Chlorpromazine: 12.5 mg IV and 12.5 mg IM. 12.5 mg IV repeated every 30 min, to a total of 50 mg, until BP controlled or an additional antihypertensive.
 Nifedipine: 10 mg sl, repeated every 30 min to a max of 4 doses until BP controlled or an additional antihypertensive.
Outcomes Woman: eclampsia, additional antihypertensive, caesarean section.
 Baby: gestation at delivery (mean).
Notes All women received phenytoin.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk “The randomised assignment took place using permutation blocks and random number tables.” 
Allocation concealment (selection bias) Unclear risk B ‐ Unclear. States “...the scheme for each patient in a sealed envelope identified with a number” ‐ but no information whether envelopes were sequentially numbered or opaque.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not reported, but regimens different.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Not reported, but regimens different.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk 60 women were randomised, but 5 women in the chlorpromazine group were excluded from the analysis as they received other medications, reducing this group to 25. Don't appear to present any data on these 5 women ‐ though this was from a translation.
Selective reporting (reporting bias) Unclear risk Unclear, article in Spanish and can not tell from translation.
Other bias Unclear risk Unclear, article in Spanish and can not tell from translation.