Skip to main content
. 2013 Jun 7;2013(6):CD001396. doi: 10.1002/14651858.CD001396.pub3

Comparison 4. SSRIs versus placebo: adverse events.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Nausea 16 3385 Odds Ratio (M‐H, Random, 95% CI) 3.43 [2.63, 4.47]
1.1 Low dose 8 1102 Odds Ratio (M‐H, Random, 95% CI) 2.24 [1.38, 3.63]
1.2 Mod dose 16 2124 Odds Ratio (M‐H, Random, 95% CI) 4.14 [2.98, 5.75]
1.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 3.78 [1.24, 11.51]
2 Insomnia or sleep disturbance 16 3388 Odds Ratio (M‐H, Random, 95% CI) 1.84 [1.36, 2.47]
2.1 Low dose 10 1252 Odds Ratio (M‐H, Random, 95% CI) 2.51 [1.39, 4.54]
2.2 Mod dose 15 1977 Odds Ratio (M‐H, Random, 95% CI) 1.53 [1.03, 2.26]
2.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 4.40 [1.45, 13.30]
3 Sexual dysfunction or decreased libido 14 2847 Odds Ratio (M‐H, Random, 95% CI) 2.26 [1.54, 3.31]
3.1 Low dose 8 1082 Odds Ratio (M‐H, Random, 95% CI) 1.98 [1.02, 3.85]
3.2 Mod dose 14 1765 Odds Ratio (M‐H, Random, 95% CI) 2.46 [1.52, 3.99]
4 Fatigue or sedation 8 951 Odds Ratio (M‐H, Random, 95% CI) 1.66 [1.09, 2.53]
4.1 Low dose 2 126 Odds Ratio (M‐H, Random, 95% CI) 1.55 [0.52, 4.56]
4.2 Mod dose 8 666 Odds Ratio (M‐H, Random, 95% CI) 1.49 [0.91, 2.43]
4.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 3.88 [1.10, 13.70]
5 Dizziness or vertigo 11 2354 Odds Ratio (M‐H, Random, 95% CI) 1.96 [1.32, 2.89]
5.1 Low dose 6 824 Odds Ratio (M‐H, Random, 95% CI) 1.46 [0.75, 2.85]
5.2 Mod dose 11 1371 Odds Ratio (M‐H, Random, 95% CI) 2.11 [1.29, 3.45]
5.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 8.57 [1.10, 66.76]
6 Tremor 4 1352 Odds Ratio (M‐H, Random, 95% CI) 5.38 [2.20, 13.16]
6.1 Low dose 3 521 Odds Ratio (M‐H, Random, 95% CI) 3.38 [0.59, 19.36]
6.2 Mod dose 4 672 Odds Ratio (M‐H, Random, 95% CI) 4.94 [1.47, 16.61]
6.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 12.85 [1.68, 98.36]
7 Somnolence/decreased concentration 7 1797 Odds Ratio (M‐H, Random, 95% CI) 4.94 [2.82, 8.63]
7.1 Low dose 4 587 Odds Ratio (M‐H, Random, 95% CI) 4.41 [1.62, 12.03]
7.2 Mod dose 7 1051 Odds Ratio (M‐H, Random, 95% CI) 4.89 [2.40, 9.96]
7.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 8.57 [1.10, 66.76]
8 Sweating 9 2051 Odds Ratio (M‐H, Random, 95% CI) 3.02 [1.79, 5.11]
8.1 Low dose 4 628 Odds Ratio (M‐H, Random, 95% CI) 3.08 [0.89, 10.73]
8.2 Mod dose 9 1264 Odds Ratio (M‐H, Random, 95% CI) 2.97 [1.59, 5.55]
8.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 3.26 [0.70, 15.11]
9 Dry mouth 9 1474 Odds Ratio (M‐H, Random, 95% CI) 2.70 [1.65, 4.41]
9.1 Low dose 3 275 Odds Ratio (M‐H, Random, 95% CI) 3.08 [0.84, 11.23]
9.2 Mod dose 9 1040 Odds Ratio (M‐H, Random, 95% CI) 2.60 [1.47, 4.58]
9.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 2.95 [0.63, 13.84]
10 Yawning 5 975 Odds Ratio (M‐H, Random, 95% CI) 4.24 [1.63, 10.99]
10.1 Low dose 3 303 Odds Ratio (M‐H, Random, 95% CI) 3.00 [0.52, 17.41]
10.2 Mod dose 5 513 Odds Ratio (M‐H, Random, 95% CI) 4.60 [1.34, 15.74]
10.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 6.92 [0.38, 125.21]
11 Asthenia/decreased energy 7 1704 Odds Ratio (M‐H, Random, 95% CI) 3.28 [2.16, 4.98]
11.1 Low dose 6 841 Odds Ratio (M‐H, Random, 95% CI) 3.18 [1.73, 5.86]
11.2 Mod dose 7 863 Odds Ratio (M‐H, Random, 95% CI) 3.36 [1.89, 5.97]
12 Diarrhoea 10 2402 Odds Ratio (M‐H, Random, 95% CI) 2.21 [1.35, 3.62]
12.1 Low dose 7 1003 Odds Ratio (M‐H, Random, 95% CI) 2.24 [0.97, 5.21]
12.2 Mod dose 10 1399 Odds Ratio (M‐H, Random, 95% CI) 2.20 [1.20, 4.03]
13 Constipation 6 996 Odds Ratio (M‐H, Random, 95% CI) 2.35 [1.04, 5.29]
13.1 Low dose 3 406 Odds Ratio (M‐H, Random, 95% CI) 2.18 [0.60, 7.95]
13.2 Mod dose 6 590 Odds Ratio (M‐H, Random, 95% CI) 2.47 [0.87, 6.98]
14 Gastrointestinal irritability or dyspepsia 5 803 Odds Ratio (M‐H, Random, 95% CI) 2.03 [0.78, 5.31]
14.1 Low dose 2 279 Odds Ratio (M‐H, Random, 95% CI) 1.69 [0.31, 9.26]
14.2 Mod dose 5 524 Odds Ratio (M‐H, Random, 95% CI) 2.21 [0.67, 7.29]
15 Headache 15 2866 Odds Ratio (M‐H, Random, 95% CI) 1.13 [0.89, 1.42]
15.1 Low dose 8 1102 Odds Ratio (M‐H, Random, 95% CI) 1.18 [0.80, 1.73]
15.2 Mod dose 15 1764 Odds Ratio (M‐H, Random, 95% CI) 1.10 [0.83, 1.46]
16 Decreased appetite 3 433 Odds Ratio (M‐H, Random, 95% CI) 1.77 [0.79, 3.98]
16.1 Low dose 1 47 Odds Ratio (M‐H, Random, 95% CI) 2.22 [0.23, 21.73]
16.2 Mod dose 3 227 Odds Ratio (M‐H, Random, 95% CI) 1.17 [0.36, 3.74]
16.3 High dose 1 159 Odds Ratio (M‐H, Random, 95% CI) 2.75 [0.76, 9.95]
17 Increased appetite 3 495 Odds Ratio (M‐H, Random, 95% CI) 1.36 [0.34, 5.46]
17.1 Low dose 1 182 Odds Ratio (M‐H, Random, 95% CI) 2.45 [0.12, 51.81]
17.2 Mod dose 3 313 Odds Ratio (M‐H, Random, 95% CI) 1.03 [0.17, 6.19]
18 Anxiety 3 397 Odds Ratio (M‐H, Random, 95% CI) 1.17 [0.45, 3.02]
18.1 Low dose 1 130 Odds Ratio (M‐H, Random, 95% CI) 2.65 [0.30, 23.45]
18.2 Mod dose 3 267 Odds Ratio (M‐H, Random, 95% CI) 0.97 [0.34, 2.77]
19 Cardiovascular symptoms 3 380 Odds Ratio (M‐H, Random, 95% CI) 3.94 [0.89, 17.39]
19.1 Mod dose 3 225 Odds Ratio (M‐H, Random, 95% CI) 3.67 [0.66, 20.44]
19.2 High dose 1 155 Odds Ratio (M‐H, Random, 95% CI) 4.89 [0.26, 92.53]
20 Respiratory disorder 4 1334 Odds Ratio (M‐H, Random, 95% CI) 0.70 [0.46, 1.06]
20.1 Low dose 4 664 Odds Ratio (M‐H, Random, 95% CI) 0.82 [0.46, 1.46]
20.2 Mod dose 4 670 Odds Ratio (M‐H, Random, 95% CI) 0.59 [0.29, 1.19]
21 Sinusitis 5 1657 Odds Ratio (M‐H, Random, 95% CI) 0.65 [0.38, 1.12]
21.1 Low dose 5 828 Odds Ratio (M‐H, Random, 95% CI) 0.84 [0.34, 2.10]
21.2 Mod dose 5 829 Odds Ratio (M‐H, Random, 95% CI) 0.48 [0.22, 1.06]
22 Infection 4 1339 Odds Ratio (M‐H, Random, 95% CI) 1.01 [0.60, 1.70]
22.1 Low dose 4 677 Odds Ratio (M‐H, Random, 95% CI) 0.84 [0.41, 1.73]
22.2 Mod dose 4 662 Odds Ratio (M‐H, Random, 95% CI) 1.13 [0.46, 2.77]