1 Nausea |
16 |
3385 |
Odds Ratio (M‐H, Random, 95% CI) |
3.43 [2.63, 4.47] |
1.1 Low dose |
8 |
1102 |
Odds Ratio (M‐H, Random, 95% CI) |
2.24 [1.38, 3.63] |
1.2 Mod dose |
16 |
2124 |
Odds Ratio (M‐H, Random, 95% CI) |
4.14 [2.98, 5.75] |
1.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
3.78 [1.24, 11.51] |
2 Insomnia or sleep disturbance |
16 |
3388 |
Odds Ratio (M‐H, Random, 95% CI) |
1.84 [1.36, 2.47] |
2.1 Low dose |
10 |
1252 |
Odds Ratio (M‐H, Random, 95% CI) |
2.51 [1.39, 4.54] |
2.2 Mod dose |
15 |
1977 |
Odds Ratio (M‐H, Random, 95% CI) |
1.53 [1.03, 2.26] |
2.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
4.40 [1.45, 13.30] |
3 Sexual dysfunction or decreased libido |
14 |
2847 |
Odds Ratio (M‐H, Random, 95% CI) |
2.26 [1.54, 3.31] |
3.1 Low dose |
8 |
1082 |
Odds Ratio (M‐H, Random, 95% CI) |
1.98 [1.02, 3.85] |
3.2 Mod dose |
14 |
1765 |
Odds Ratio (M‐H, Random, 95% CI) |
2.46 [1.52, 3.99] |
4 Fatigue or sedation |
8 |
951 |
Odds Ratio (M‐H, Random, 95% CI) |
1.66 [1.09, 2.53] |
4.1 Low dose |
2 |
126 |
Odds Ratio (M‐H, Random, 95% CI) |
1.55 [0.52, 4.56] |
4.2 Mod dose |
8 |
666 |
Odds Ratio (M‐H, Random, 95% CI) |
1.49 [0.91, 2.43] |
4.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
3.88 [1.10, 13.70] |
5 Dizziness or vertigo |
11 |
2354 |
Odds Ratio (M‐H, Random, 95% CI) |
1.96 [1.32, 2.89] |
5.1 Low dose |
6 |
824 |
Odds Ratio (M‐H, Random, 95% CI) |
1.46 [0.75, 2.85] |
5.2 Mod dose |
11 |
1371 |
Odds Ratio (M‐H, Random, 95% CI) |
2.11 [1.29, 3.45] |
5.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
8.57 [1.10, 66.76] |
6 Tremor |
4 |
1352 |
Odds Ratio (M‐H, Random, 95% CI) |
5.38 [2.20, 13.16] |
6.1 Low dose |
3 |
521 |
Odds Ratio (M‐H, Random, 95% CI) |
3.38 [0.59, 19.36] |
6.2 Mod dose |
4 |
672 |
Odds Ratio (M‐H, Random, 95% CI) |
4.94 [1.47, 16.61] |
6.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
12.85 [1.68, 98.36] |
7 Somnolence/decreased concentration |
7 |
1797 |
Odds Ratio (M‐H, Random, 95% CI) |
4.94 [2.82, 8.63] |
7.1 Low dose |
4 |
587 |
Odds Ratio (M‐H, Random, 95% CI) |
4.41 [1.62, 12.03] |
7.2 Mod dose |
7 |
1051 |
Odds Ratio (M‐H, Random, 95% CI) |
4.89 [2.40, 9.96] |
7.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
8.57 [1.10, 66.76] |
8 Sweating |
9 |
2051 |
Odds Ratio (M‐H, Random, 95% CI) |
3.02 [1.79, 5.11] |
8.1 Low dose |
4 |
628 |
Odds Ratio (M‐H, Random, 95% CI) |
3.08 [0.89, 10.73] |
8.2 Mod dose |
9 |
1264 |
Odds Ratio (M‐H, Random, 95% CI) |
2.97 [1.59, 5.55] |
8.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
3.26 [0.70, 15.11] |
9 Dry mouth |
9 |
1474 |
Odds Ratio (M‐H, Random, 95% CI) |
2.70 [1.65, 4.41] |
9.1 Low dose |
3 |
275 |
Odds Ratio (M‐H, Random, 95% CI) |
3.08 [0.84, 11.23] |
9.2 Mod dose |
9 |
1040 |
Odds Ratio (M‐H, Random, 95% CI) |
2.60 [1.47, 4.58] |
9.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
2.95 [0.63, 13.84] |
10 Yawning |
5 |
975 |
Odds Ratio (M‐H, Random, 95% CI) |
4.24 [1.63, 10.99] |
10.1 Low dose |
3 |
303 |
Odds Ratio (M‐H, Random, 95% CI) |
3.00 [0.52, 17.41] |
10.2 Mod dose |
5 |
513 |
Odds Ratio (M‐H, Random, 95% CI) |
4.60 [1.34, 15.74] |
10.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
6.92 [0.38, 125.21] |
11 Asthenia/decreased energy |
7 |
1704 |
Odds Ratio (M‐H, Random, 95% CI) |
3.28 [2.16, 4.98] |
11.1 Low dose |
6 |
841 |
Odds Ratio (M‐H, Random, 95% CI) |
3.18 [1.73, 5.86] |
11.2 Mod dose |
7 |
863 |
Odds Ratio (M‐H, Random, 95% CI) |
3.36 [1.89, 5.97] |
12 Diarrhoea |
10 |
2402 |
Odds Ratio (M‐H, Random, 95% CI) |
2.21 [1.35, 3.62] |
12.1 Low dose |
7 |
1003 |
Odds Ratio (M‐H, Random, 95% CI) |
2.24 [0.97, 5.21] |
12.2 Mod dose |
10 |
1399 |
Odds Ratio (M‐H, Random, 95% CI) |
2.20 [1.20, 4.03] |
13 Constipation |
6 |
996 |
Odds Ratio (M‐H, Random, 95% CI) |
2.35 [1.04, 5.29] |
13.1 Low dose |
3 |
406 |
Odds Ratio (M‐H, Random, 95% CI) |
2.18 [0.60, 7.95] |
13.2 Mod dose |
6 |
590 |
Odds Ratio (M‐H, Random, 95% CI) |
2.47 [0.87, 6.98] |
14 Gastrointestinal irritability or dyspepsia |
5 |
803 |
Odds Ratio (M‐H, Random, 95% CI) |
2.03 [0.78, 5.31] |
14.1 Low dose |
2 |
279 |
Odds Ratio (M‐H, Random, 95% CI) |
1.69 [0.31, 9.26] |
14.2 Mod dose |
5 |
524 |
Odds Ratio (M‐H, Random, 95% CI) |
2.21 [0.67, 7.29] |
15 Headache |
15 |
2866 |
Odds Ratio (M‐H, Random, 95% CI) |
1.13 [0.89, 1.42] |
15.1 Low dose |
8 |
1102 |
Odds Ratio (M‐H, Random, 95% CI) |
1.18 [0.80, 1.73] |
15.2 Mod dose |
15 |
1764 |
Odds Ratio (M‐H, Random, 95% CI) |
1.10 [0.83, 1.46] |
16 Decreased appetite |
3 |
433 |
Odds Ratio (M‐H, Random, 95% CI) |
1.77 [0.79, 3.98] |
16.1 Low dose |
1 |
47 |
Odds Ratio (M‐H, Random, 95% CI) |
2.22 [0.23, 21.73] |
16.2 Mod dose |
3 |
227 |
Odds Ratio (M‐H, Random, 95% CI) |
1.17 [0.36, 3.74] |
16.3 High dose |
1 |
159 |
Odds Ratio (M‐H, Random, 95% CI) |
2.75 [0.76, 9.95] |
17 Increased appetite |
3 |
495 |
Odds Ratio (M‐H, Random, 95% CI) |
1.36 [0.34, 5.46] |
17.1 Low dose |
1 |
182 |
Odds Ratio (M‐H, Random, 95% CI) |
2.45 [0.12, 51.81] |
17.2 Mod dose |
3 |
313 |
Odds Ratio (M‐H, Random, 95% CI) |
1.03 [0.17, 6.19] |
18 Anxiety |
3 |
397 |
Odds Ratio (M‐H, Random, 95% CI) |
1.17 [0.45, 3.02] |
18.1 Low dose |
1 |
130 |
Odds Ratio (M‐H, Random, 95% CI) |
2.65 [0.30, 23.45] |
18.2 Mod dose |
3 |
267 |
Odds Ratio (M‐H, Random, 95% CI) |
0.97 [0.34, 2.77] |
19 Cardiovascular symptoms |
3 |
380 |
Odds Ratio (M‐H, Random, 95% CI) |
3.94 [0.89, 17.39] |
19.1 Mod dose |
3 |
225 |
Odds Ratio (M‐H, Random, 95% CI) |
3.67 [0.66, 20.44] |
19.2 High dose |
1 |
155 |
Odds Ratio (M‐H, Random, 95% CI) |
4.89 [0.26, 92.53] |
20 Respiratory disorder |
4 |
1334 |
Odds Ratio (M‐H, Random, 95% CI) |
0.70 [0.46, 1.06] |
20.1 Low dose |
4 |
664 |
Odds Ratio (M‐H, Random, 95% CI) |
0.82 [0.46, 1.46] |
20.2 Mod dose |
4 |
670 |
Odds Ratio (M‐H, Random, 95% CI) |
0.59 [0.29, 1.19] |
21 Sinusitis |
5 |
1657 |
Odds Ratio (M‐H, Random, 95% CI) |
0.65 [0.38, 1.12] |
21.1 Low dose |
5 |
828 |
Odds Ratio (M‐H, Random, 95% CI) |
0.84 [0.34, 2.10] |
21.2 Mod dose |
5 |
829 |
Odds Ratio (M‐H, Random, 95% CI) |
0.48 [0.22, 1.06] |
22 Infection |
4 |
1339 |
Odds Ratio (M‐H, Random, 95% CI) |
1.01 [0.60, 1.70] |
22.1 Low dose |
4 |
677 |
Odds Ratio (M‐H, Random, 95% CI) |
0.84 [0.41, 1.73] |
22.2 Mod dose |
4 |
662 |
Odds Ratio (M‐H, Random, 95% CI) |
1.13 [0.46, 2.77] |