Comparison 5. SSRIs versus placebo ‐ psychological symptoms (end scores).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Low dose SSRI	3	470	Std. Mean Difference (IV, Random, 95% CI)	‐0.38 [‐0.57, ‐0.20]
1.1 Luteal administration	1	210	Std. Mean Difference (IV, Random, 95% CI)	‐0.36 [‐0.63, ‐0.08]
1.2 Continuous administration	2	260	Std. Mean Difference (IV, Random, 95% CI)	‐0.40 [‐0.65, ‐0.16]
2 Moderate dose SSRI	5	795	Std. Mean Difference (IV, Random, 95% CI)	‐0.51 [‐0.65, ‐0.37]
2.1 Luteal administration	1	198	Std. Mean Difference (IV, Random, 95% CI)	‐0.60 [‐0.88, ‐0.31]
2.2 Continuous administration	4	597	Std. Mean Difference (IV, Random, 95% CI)	‐0.48 [‐0.64, ‐0.32]