Comparison 11. SSRIs versus placebo ‐ irritability (end scores).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Low dose SSRI	1	53	Std. Mean Difference (IV, Random, 95% CI)	‐0.57 [‐1.12, ‐0.02]
1.1 Luteal administration	1	53	Std. Mean Difference (IV, Random, 95% CI)	‐0.57 [‐1.12, ‐0.02]
2 Moderate dose SSRI	5	655	Std. Mean Difference (IV, Random, 95% CI)	‐0.56 [‐0.72, ‐0.40]
2.1 Luteal administration	2	282	Std. Mean Difference (IV, Random, 95% CI)	‐0.65 [‐0.93, ‐0.36]
2.2 Continuous administration	3	373	Std. Mean Difference (IV, Random, 95% CI)	‐0.51 [‐0.73, ‐0.30]