Crnobaric 1998.

Methods	Randomised, double‐blind, placebo‐controlled, parallel study
Participants	Country: Yugoslavia Site: No details in abstract Recruitment: 25 women randomised. Age 18‐40 years (mean 29.5). See Table of bias for details of attrition Inclusion: Aged 18 to 40 with regular menstrual cycles. Meeting DSM‐IV criteria for PMDD Exclusion: Current history of major depressive disorder, current mental disorder
Interventions	Screening: Two cycle screening Placebo run in: None Interventions: Fluoxetine 20mg (n=14) versus placebo (n=11) taken daily Duration: Two cycles of treatment Timing of administration: No details as to when in the cycle medication was commenced Summary measures: No details as to whether the data was the mean of two treatment cycles or the last cycle data
Outcomes	Clinical Global Impression Scale (CGI); Hamilton Rating Scale of Depression (HAM‐D); Calendar of Premenstrual Experience (COPE)
Notes	No details of funding source
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	States randomised. Method not reported
Allocation concealment (selection bias)	Unclear risk	Method not reported
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Double blind, no further details
Incomplete outcome data (attrition bias) All outcomes	Low risk	25 women randomised. No attrition
Selective reporting (reporting bias)	Unclear risk	Three symptom scoring questionnaires used but results reported for only two
Other bias	Unclear risk	Few details available as not published in full text