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. 2007 Jul 18;2007(3):CD001434. doi: 10.1002/14651858.CD001434.pub2

Smith 1977.

Methods RCT
 Study aim clearly defined: yes
 Blinded assesor of primary outcome: yes
 Double blind study: yes
 Participants comparable at baseline for age: yes Sex: not stated Duration of complaint: yes
 Inclusion and exclusion criteria specified: not stated
 Interventions well described: yes
 Assessment of compliance: yes
 Intention to treat analysis: yes
 A Priori sample size calculation: not stated
 Fungi identified: yes
 Distribution of species between groups: not stated
 Adverse events reported: yes
 Number of drop outs stated: nine
Participants Total evaluable sample size: 104
 Treatment setting: Health Center
Interventions a. 20% zinc undecylenate and 2% undecylenic acid ‐ new commercial powder
 Duration: six weeks
 Frequency: applied once daily
 b. 20% Undecylenate and 2% undecylenic acid ‐ over the counter powder
 Duration: six weeks
 Frequency: applied once daily
 c. Placebo powder
 Duration: six weeks
 Frequency: applied once daily
Outcomes Primary outcome: cure
 Adverse events: a. two patients with pruritus
Notes Culture results only
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate