Table 2.
Headache Patterns of Patient in Different Treatment Groups
| IFNβ1-a IM (n=223, 28.02%) | IFNβ1-a SC 22 µg (n=89, 11.18%) | IFNβ1-a SC 44 µg (n=259, 32.53%) | IFNβ1-b SC (n=225, 28.27%) | Total (n=796) | |||
|---|---|---|---|---|---|---|---|
| Pre-existing headache not worsened by IFN-β | Number | 13 | 11 | 25 | 74 | 123 (15.45%) | |
| Characters | Migraine | 9 | 7 | 17 | 51 | 84 | |
| Tension type | 3 | 4 | 6 | 20 | 33 | ||
| Others | 1 | 0 | 2 | 3 | 6 | ||
| Pre-existing headache worsened by IFN-β | Number | 55 | 14 | 61 | 23 | 153 (19.22%) | |
| Characters | Migraine | 17 | 5 | 19 | 12 | 53 | |
| Tension type | 36 | 8 | 40 | 9 | 93 | ||
| Others/unclassified | 2 | 1 | 2 | 2 | 7 | ||
| Denovo headache not related to IFN-β | 18 | 18 | 31 | 55 | 122 (15.33%) | ||
| Denovo headache related to IFN-β commencement | Number | 97 | 8 | 105 | 24 | 234 (29.39%) | |
| Character | Migraine | 21/97 | 1/8 | 18/105 | 6/24 | 46/234 | |
| Tension | 74/97 | 7/8 | 83/105 | 18/24 | 182/234 | ||
| Others/unclassified | 2/97 | 0 | 4/105 | 0 | 6/234 | ||
| No headache (n=165) | 40 | 38 | 37 | 49 | 164 (20.60%) | ||
Abbreviations: IM, intramuscular; IFN-β, interferon-beta; SC, subcutaneous.