Figure EV1. Expression levels of CRISPRa‐targeted genes and neighboring genes in human RPE‐1 cells.

• A–H
  Top panels: domainograms showing changes in NL interactions around genes activated by CRISPRa. Domainograms are same as in Fig 2C. Middle panels: log₂ mRNA expression (normalized read counts in 50 bp bins) as determined by mRNA‐seq of CRISPRa‐activated cells (red, upward y‐axis) compared to untransfected control cells (blue, downward y‐axis). Note that only introns give detectable reads. Data are average of two independent replicate experiments each. Bottom panels: gene annotation track. Each CRISPRa‐targeted gene is highlighted in green; targeted promoters are marked by vertical green dotted line.