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. Author manuscript; available in PMC: 2020 Oct 5.
Published in final edited form as: Int J Pharm. 2019 Aug 14;569:118627. doi: 10.1016/j.ijpharm.2019.118627

Table 2:

Examples of cells encapsulated AMS (arranged according for formulation method)

Therapeutic agent Formulation method Materials used Findings Reference
Dental pulp stem cells (DPSC) Emulsification Calcium-AMS Enhanced osteogenic potential of cells, maintained high cell viability for bone tissue regeneration (Kanafi et al., 2014)
Enterococcus faecalis Emulsification Milk, alginate Good tolerance to stimulated gastric fluid and bile salt solution (1.0 or 2.0%), improved storage stability of E. faecalis (Shi et al., 2016)
Allogeneic pancreatic islet cells Emulsification Chemically modified alginate derivative Z1-Y15 Three of the several chemically modified AMS elicited a reduced foreign body response, are now in clinical trials. (Bochenek et al., 2018)
Mesenchyma l stem cells (MSC) Microfluidics with calcium crosslinking Sodium alginate, calcium chloride-ethylenediam ine tetra acetic acid. MSC encapsulated within homogenous AMS, stable cell growth and proliferation for 15 days. (Utech et al., 2015)
Modified human pancreatic islets cells (1.1B4) Microfluidics Alginatepoly-L-lysine-copolymer Microspheres formulated as microcapsules in the static state and using microfluidics in dynamic state. Cell viability and glucose simulated insulin secretion better in microcapsules formulated by dynamic microfluidics method (Acarregui et al., 2018)
MSC Co-axial air-flow droplet generator Alginate-polyethylene glycol microspheres Encapsulated MSC displayed anti-fibrotic and anti-inflammatory effects on liver fibrosis in mice due to secretion of soluble factors (Meier et al., 2015)