Table 2.
Tissue Type (Origin) | Heteroplasmy Levels (%) by RFLP | mtDNA Copy Number MT-ND1/18S5 |
---|---|---|
Central nervous system | ||
Putamen | 80.84 | 12.85 |
Caudate nucleus | 79.26 | 24.81 |
Mammillary body | 76.80 | 29.66 |
Hypothalamus | 75.70 | 15.88 |
Thalamus | 74.71 | 33.06 |
Internal capsule | 76.71 | 15.83 |
Globus pallidus | 84.63 | 23.22 |
Visual cortex | 83.67 | 17.79 |
Pons | 90.04 | 6.81 |
Medulla oblongata | 90.75 | 21.41 |
White matter | 90.69 | 9.72 |
Cerebellar vermis | 89.43 | 21.51 |
Spinal cord | 90.53 | 10.42 |
Dorsal root ganglion | 91.16 | 2.31 |
Peripheral organs | ||
Liver | 78.48 | 8.75 |
Bladder | 82.02 | 11.06 |
M. obliqus superior | 72.93 | 24.35 |
M. rectus medialis | 71.37 | 29.95 |
M. rectus superior | 73.02 | 36.17 |
M. rectus inferior | 71.36 | 23.43 |
M. iliopsoas | 68.16 | 36.29 |
M. vastus lat. | 65.91 | 14.65 |
M. pectoralis | 73.68 | 12.76 |
M. biceps brachii | 81.20 | 20.08 |
Tongue muscle base | 84.64 | 15.73 |
Heart muscle (left) | 81.40 | 27.16 |
Heart muscle (right) | 77.04 | 11.64 |
AV-node | 71.38 | 12.60 |
Kidney | 63.28 | 12.42 |
Sural nerve | 90.76 | 6.25 |
RFLP: Restriction fragment length polymorphism; AV- node: Atrioventricular node.