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. 2020 Feb 21;11(2):226. doi: 10.3390/genes11020226

Figure 5.

Figure 5

Various immune cell signatures correlated to specific LVs that differentiate tumor types in NF1. (A) CIBERSORT deconvolution of bulk nerve sheath tumor expression data predicted the presence of activated mast cells and M2 macrophages and resting CD4+ memory T cells in all of the tested tumor types. (B) MCP-counter based deconvolution of bulk nerve sheath tumor expression data predicted the presence of cancer-associated fibroblasts across all tumor types, and diversity in T cell population across tumor types. (C) Correlation of CIBERSORT immune score (x-axis) with expression of latent variable 546 highlighted the increased presence of activated mast cells and resting dendritic cells in cNFs (circles). (D) Top 20 gene loadings of LV 546. (E) Correlation of MCP-counter score of Tell infiltration (x-axis) with LV 540. (F) Top 20 gene loadings of LV 540.