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. 2020 Jan 30;18(2):90. doi: 10.3390/md18020090

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© 2020 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Domain structure of the natural product megasynthases from Bigelloweilla natans and tentatively proposed structure of the products. (a) Gene 18 on contig 2069 (NCBI accession ADNK01001542.1) (b) Gene 5 on contig 690 (NCBI accession ADNK01003012.1). (c) Gene 25 on contig 859 (NCBI accession ADNK01002829.1). (d) Gene 6–7 on contig 3305 (NCBI accession ADNK01000237.1). A = Adenylation domain. ACP = Acyl carrier protein. C = Condensation domain. E = Epimerase. KS = Ketosynthase. AT = Acyl transferase. KR = Ketoreductase. TE = Thioesterase.